Hydrogels for cardiac tissue engineering
نویسندگان
چکیده
Cardiac failure is a critical condition that results in life-threatening consequences. Due to a limited number of organ donors, tissue engineering has emerged to generate functional tissue constructs and provide an alternative mean to repair and regenerate damaged heart tissues. In this paper, we review the emerging directions associated with cardiac tissue engineering approaches. In particular, we discuss the use of hydrogels in repair and regeneration of damaged hearts. Because of their tissue-like biological, chemical and mechanical properties, hydrogels represent a potentially powerful material for directing cells into functional cardiac tissues. Herein, we will summarize both traditional and next-generation hydrogels with conductive, elastomeric and oxygen-releasing capabilities that can promote vascularization and stem cell differentiation to form properly functioning cardiac tissues. NPG Asia Materials (2014) 6, e99; doi:10.1038/am.2014.19; published online 16 May 2014
منابع مشابه
Hydrogels for Cardiac Tissue Engineering
Cardiac tissue regeneration is an integrated process involving both cells and supporting matrix. Cardiomyocytes and stem cells are utilized to regenerate cardiac tissue. Hydrogels, because of their tissue-like properties, have been used as supporting matrices to deliver cells into infarcted cardiac muscle. Bioactive and biocompatible hydrogels mimicking biochemical and biomechanical microenviro...
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